The airport has daily flights to Madrid and Barcelona and weekly connections to several secondary airports in many European cities of Europe (London, Edinburgh, Rome, Brussels, Berlin, Dusseldorf, Dublin, ...) operated by the low-cost company Ryan air.
The city can be reached from the airport either by taxi (with a cost of, approximately, 10€) or using a bus that connects with the city center with a frequency of 30 minutes (the ride takes about 10 minutes and costs 2.5€).
Another possibility to reach the city is to fly to the much larger airport of Bilbao and then make the trip to Santander by bus. In order to do so it is necessary to go Bilbao central bus station and then take a bus to Santander (the trip takes 1hour 30 minutes). Schedules can be found in the ALSA webpage.